International framework

Governance refers to a range of steering and rule-making functions carried out by decision-makers that directly impact the availability, accessibility and standards of delivery of radioligand therapy. Governance may come from health or energy system decision-makers in the form of policy and plans, but it also includes guidelines and the best practice from the clinical community.

Regulation and reimbursement define why, when and how radioligand therapy should be provided and paid for. This essential component of the health system is led by various national, and sometimes international, organisations and ensures that medicines are delivered safely, effectively and sustainably.

Identified need is the potential need or demand for radioligand therapy among people with cancer. There are many components required to fully understand a need for an intervention, including epidemiological data, levels of patient and healthcare professional awareness, and referral patterns. Such information is essential in planning services.

Service provision encompasses the inputs and outputs required for the provision of radioligand therapy. This includes the healthcare workforce and infrastructure required to ensure radioligand therapy services are delivered effectively and efficiently to the people who need them.

Health information refers to data that are collected, analysed and synthesised to support decision-making around radioligand therapy. Comprehensive data collection efforts spanning clinical, patient, real-world and economic data points are essential to understand how radioligand therapy is used and how services can be improved.